Grey’s Anatomy Season 22 continues to deliver gripping storylines as the team at Grey Sloan Memorial Hospital balances high-stakes medical cases with personal challenges. In the upcoming episode, Jesse Williams returns as the beloved Dr. Jackson Avery. Episode 4, titled “Goodbye Horses”, premieres on ABC on Thursday, October 30, 2025, at 10 PM ET and will be available for streaming on Hulu the following day.In Grey's Anatomy Season 22 Episode 4, the interns at the hospital will be seen handling an unusual trauma case. Meredith will get into a surprising partnership to treat a complicated breast reconstruction procedure. Jesse Williams returns to guest-star in the episode as Jackson.Grey's Anatomy Season 22 Episode 4 release and streaming details Grey's Anatomy Season 22 Episode 4, titled ‘Goodbye Horses’, will air on Thursday, October 30, 2025, at 10 PM ET/9 PM CT on ABC. The episode will be available to stream the following day on Hulu. View this post on Instagram Instagram PostHulu’s standard plan is available at $11.99/per month. The premium plan for the streaming service that comes with no ads is priced at $18.99/per month. Episodes of Grey's Anatomy Season 22 will be available on the streaming platform.Grey's Anatomy Season 22 Episode 4 Cast details Here is a look at some of the cast members for Grey's Anatomy Season 22 Episode 4 View this post on Instagram Instagram PostEllen Pompeo – Dr. Meredith GreyJesse Williams - Jackson AveryChandra Wilson – Dr. Miranda BaileyJames Pickens Jr. – Dr. Richard WebberKevin McKidd – Owen HuntCamilla Luddington – Dr. Jo WilsonJason George – Ben WarrenKim Raver – Dr. Teddy AltmanChris Carmack – Dr. Atticus LincolnAlexis Floyd – Simone GriffinHarry Shum Jr. – Dr. Benson “Blue” KwanAdelaide Kane – Dr. Jules MillinNiko Terho – Lucas AdamsWhat to expect in Grey’s Anatomy Season 22 Episode 4?In the previous episode of Grey’s Anatomy Season 22, we found the surgical team performing a high-risk lung transplant. Bailey was also seen handling the dispute between Lucas and Bryant like the true leader she is, as she dealt with a trauma patient. Meanwhile, Teddy finally confesses about her ongoing divorce to Jo, who encourages her to focus on her happiness above all, and she does. And Blue seems to have started on the wrong foot with the new plastics fellow, Kavita Mohanty. View this post on Instagram Instagram PostGrey’s Anatomy Season 22 Episode 4, titled ‘Goodbye Horses’, will see the interns encounter a bizarre case that will leave them scrambling for answers. On the other hand, Meredith has her work cut out for her as she is faced with a challenging breast reconstruction case. Link, who was undergoing treatment after being injured in the explosion at the hospital, is getting discharged. View this post on Instagram Instagram PostHowever, the cherry on the cake for fans is the return of Jackson Avery to the hospital in Grey’s Anatomy Season 22. In the teaser, we find Jackson welcomed by the staff. That said, his role in the episode remains to be seen.The logline for the Grey's Anatomy Season 22 episode, as per Rotten Tomatoes, states,“The interns juggle a bizarre trauma, while a complex breast reconstruction forces Meredith into a tense partnership.”Watch Grey’s Anatomy Season 22 Episode 4 on ABC at 10 PM ET on October 30, 2025. The episodes are also available to stream on Hulu.ALSO READ: Grey's Anatomy Season 22 Episode 3 recap: High-risk surgery keeps the team on their toesFor more stories on shows, follow SoapCentral