Grey's Anatomy season 22 fans are in for an emotional rollercoaster as Season 22 continues to delve into more complex cases and relationship undercurrents. Episode 5, titled ‘Sometimes I Feel Like a Motherless Child’, is all set to air on ABC on Thursday, November 6, 2025, at 10 PM ET. The episode will be available to stream on Hulu the next day.In the previous episode of Grey's Anatomy Season 22, we saw Meredith get into an argument with Jackson and finally decide to head back to Boston to continue her research on Alzheimer’s disease. Meanwhile, Teddy comes face-to-face with Nora, and they share a heartwarming moment about their current lives. Also, Link is discharged and eager to get back to work.In Grey's Anatomy Season 22 Episode 5, we find Jo facing a challenging case with an expectant mother. Blue and Jules are caring for a diabetic patient that leads to some complications, and Simone learns an unexpected detail about her patient.Grey's Anatomy Season 22 Episode 5 release and streaming detailsGrey's Anatomy Season 22 Episode 5, titled ‘Sometimes I Feel Like a Motherless Child’, will premiere on ABC on Thursday, November 6, 2025, at 10 PM ET/9 PM CT. The episode will be available on the streaming platform Hulu the following day. View this post on Instagram Instagram PostTo watch Grey's Anatomy Season 22 on Hulu, choose from various subscription options. The Disney+ and Hulu bundle with ads is available at $12.99 per month. The premium plan with no ads is priced at $19.99 per month.Grey's Anatomy Season 22 Episode 5 Cast The beloved medical professionals of Grey Sloan Memorial Hospital will be returning for Grey's Anatomy Season 22 Episode 5. Here is a look at some of the cast members: View this post on Instagram Instagram PostChandra Wilson – Dr. Miranda BaileyJames Pickens Jr. – Dr. Richard WebberKevin McKidd – Owen HuntCamilla Luddington – Dr. Jo WilsonJason George – Ben WarrenKim Raver – Dr. Teddy AltmanChris Carmack – Dr. Atticus LincolnAlexis Floyd – Simone GriffinHarry Shum Jr. – Dr. Benson “Blue” KwanAdelaide Kane – Dr. Jules MillinNiko Terho – Lucas AdamsTrevor Jackson – Wes BryantAnita Kalathara – Dr. Kavita MohantyEllen Pompeo – Dr. Meredith GreyAnthony Hill – Dr. Winston NduguWhat to expect in Grey's Anatomy Season 22 Episode 5?In the last episode of Grey's Anatomy Season 22, we saw Meredith preparing to leave the hospital to continue her research, while Jackson returned to work in plastics. Blue extended an olive branch to Mohanty when he stepped out during a surgery so she could scrub in. Link got discharged and was keen to return to work. Owen met Nora at the hospital, and the two headed out for dinner, while Teddy and Cass decided to work on their relationship. View this post on Instagram Instagram PostIn the upcoming episode, a heavily pregnant Jo is handling a complex case involving an expectant mother. Meanwhile, Blue and Jules face a setback while caring for their diabetic patient, and Simone makes a surprising discovery while treating her own.As per Rotten Tomatoes, the logline for Season 22 Episode 5, titled ‘Sometimes I Feel Like a Motherless Child’, reads:Jo navigates a challenging case with a pregnant mother; Blue and Jules care for a diabetic patient; Simone treats a patient with a surprising revelation.Watch Grey's Anatomy Season 22 Episode 5 on ABC at 10 PM ET on November 6, 2025. The episode will also be available to stream on Hulu.ALSO READ: Grey’s Anatomy Season 22 Episode 4 recap: Meredith and Jackson are at loggerheadsFor more stories on shows, follow SoapCentral